منابع مشابه
1(II) collagen chain gene (Col2a1), aggrecan (Acan) and the 2(XI) collagen chain gene (Col11a2); it sustains the survival of proliferative chondrocytes during development (Ikegami et al., 2011); SOX9 overexpression in proliferative chondrocytes suppresses their hypertrophy (Akiyama
INTRODUCTION Vertebrate bones develop through membranous or endochondral ossification. Except for craniofacial bones and the clavicle, all bones are established through the latter process (Olsen et al., 2000; Karsenty et al., 2009). At the onset of endochondral bone formation, mesenchymal cells first undergo condensation, followed by differentiation of cells within these condensations into chon...
متن کاملCollagen chain composition and collagen gene expression in acne keloids.
Keloids are thick scars that grow beyond the boundaries of the original skin damage. Most lesions appear within one year of skin inflammation including burns, surgery and acne vulgaris. They are characterized by an excessive accumulation of extracellular mamx components. Keloid waning results from increased activity of fibroblasts in the dermis with imbalance between synthesis and breakdown of ...
متن کاملThe alpha 3 chain of type IV collagen prevents activation of human polymorphonuclear leukocytes.
Our initial observation that type I collagen activates polymorphonuclear leukocytes (PMN) prompted the testing of the activating potential of type IV collagen. It was noted, however, that type IV collagen isolated from bovine lens capsule did not activate PMN but rather prevented their stimulation by N-formylmethionyl-leucyl-phenylalanine, phorbol myristate acetate, or type I collagen. This obs...
متن کاملHuman amniotic membrane, like corneal epithelial basement membrane, manifests the alpha5 chain of type IV collagen.
PURPOSE To reexamine whether the alpha5 chain of type IV (alpha5[IV]) collagen, thought to be absent, is in fact present in human amniotic membrane. METHODS Cryosections of human amniotic membrane obtained at Cesarean section were immunohistochemically examined for the presence of alpha5(IV), with or without inclusion of the denaturing step. Amniotic membrane was digested with collagenase to ...
متن کاملAutosomal dominant and recessive osteochondrodysplasias associated with the COL11A2 locus
Identifying mutations that cause specific osteochondrodysplasias will provide novel insights into the function of genes that are essential for skeletal morphogenesis. We report here that an autosomal dominant form of Stickler syndrome, characterized by mild spondyloepiphyseal dysplasia, osteoarthritis, and sensorineural hearing loss, but no eye involvement, is caused by a splice donor site muta...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)80086-2